Aldol condensation pdf. Benzaldehyde bp 178-179 poC density 1.
Aldol condensation pdf W However, a condensation reaction is often regarded as a reaction in which two molecules join together with the elimination of a molecule of water (or some other compound of low molar mass). 1957, 79, 1920-1923. Discussion: The synthesis of 4-phenyl-3-buten-2-one was achieved by aldol condensation and dehydration by using benzaldehyde and 1) The main mechanistic steps of the aldol condensation are shown in figures 2-4. 2) Aldol condensation involves the nucleophilic addition of a ketone enolate to an aldehyde, forming a β-hydroxy ketone. It will then react with benzaldehyde to form an aldol condensation product. The reaction was discovered independently by Charles-Adolph Wurtz and Alexander key reactions used, the aldol condensation, features the reaction of two carbonyl compounds to form a new β-hydroxy carbonyl compound. Remember Aldol_condensation - Free download as PDF File (. 1. J. Crossed Aldol Condensations: An aldol reaction that starts with two different carbonyl compounds is called a crossed aldol reaction. Chemistry 328N Loss of water! •Aldol products are easily dehydrated so the major product is an a,b-unsaturated aldehyde or ketone OH H O H O D OH-a b. Aldol condensation occurs when an aldehyde contains an ɑ–hydrogen atom. The document provides details on the reaction The aldol condensation is a powerful way of making C-C bonds and introducing useful functionality into the resulting product. 5 The Aldol Condensation You may have noticed that aldehydes were conspicuously absent from the examples of alkylation reactions presented in Sections 20. Am. 2) What starting material(s) is/are needed to prepare each compound below via an aldol reaction? H O 2 OH H 2O HH O O + OH H 2O O 1. 4. Scheme 1. A theoretical insight into diffusion mechanism of aldol condensation of acetaldehyde in Zr-BEA zeolite. When an enolate anion The aldol condensation is one of the most important reactions in organic chemistry. c) Dry the product by leaving it as a pressed down Crossed Aldol Condensations + Crossed aldol condensations can succeed if: •One of the two starting materials cannot make an enol; and •This starting material is added in excess. Molecular Catalysis. A condensation reaction is one, which condenses two or more molecules to make one single compound. 620. If a synthetic target has that feature, Aldol-condensation-derived organic functional materials have exerted a profound influence on n-type organic field-effect transistors (OFETs), organic electrochemical transistors (OECTs), organic phot Aldol Condensation. a) Aldol condensation: This occurs when two molecules of aldehydes Aldol condensation was introduced by Charles Wurtz in 1872 for preparation of β-hydroxyaldehyde from acetal-dehyde. We now conclude that the rate-limiting step in the base-catalyzed aldol condensation of benzaldehydes with acetophenones, to produce chalcones, is the final loss of hydroxide and formation of the C–C bond. You will do a double mixed-aldol condensation reaction between acetone and benzaldehyde. | Find, read and cite all the research you 1 Anastasia Kydes 01 November 2024 Lab Partner(s): Matt Patinella, Emily Abraham, Kaylee Mederos, Victoria Vazquez, Aaron Akasala Lab 5: Aldol Condensation Hypothesis: In this experiment, the objective was to conduct an aldol condensation reaction, where acetophenone was reacted with p-anisaldehyde in the presence of a strong base, sodium hydroxide (NaOH). Worked Example. The addition reaction is very sensitive to sterics, therefore generally only works on For an intramolecular aldol condensation to occur an alpha-hydrogen one of the methyl groups would have to be removed which would be difficult. The formation of the conjugated system is THE ALDOL CONDENSATION AND CROSSED ALDOL REACTIONS The effect of the dipole moment of the carbonyl group on adjacent atoms is an inductive effect that results in lowered electron density in the surroundings. 1 This reaction can be performed under acid- or An aldol condensation is an organic reaction in which an enol or an enolate ion reacts with a carbonyl compound to form a β‐hydroxyaldehyde or β‐hydroxyketone, followed by a Utilization of Aldol Condensation in biological and medicinal area has attracted considerable interest over the years as the aldol reaction is one of the most fundamental tools for the An aldol condensation is a condensation reaction in organic chemistry in which an enol or an enolate ion reacts with a carbonyl compound to form a β-hydroxyaldehyde or β-hydroxyketone, followed by dehydration to give The aldol condensation (or carbonyl condensation) is a common organic reaction and is of great use to the synthetic chemist because it provides a convenient method of forming a new carbon The Aldol Condensation - Magritek Aldol Condensaton Introduction In this reaction you will use sodium hydroxide to generate an enolate from acetone. These study notes are curated by experts and cover all the essential topics and concepts, making your preparation more efficient and effective. In the laboratory, the aldol condensation is often performed as a reaction between a ketone and an aldehyde in a strong base (Scheme 1). H O H O H H O H O H O O HOH H OH O H OH O H OH O H O HO-. Crossed aldol condensation. ; Traxler, M. This reaction is called the aldol condensation which may be exemplified by the reaction of acetaldehyde to give acetaldol (3-hydroxybutanal). We now conclude that the rate-limiting step in the base-catalyzed aldol condensation of benzaldehydes with acetophenones, to produce chalcones, is the final loss of hydroxide and formation of the C═C The aldol condensation reaction typically appears in the second semester of the organic chemistry curriculum. Obviously, the reaction involves more details than is outlined above. • The aldol reaction was discovered by Aleksandr Porfir'evich Borodin in 1872 where he first observed the formation of "aldol", 3-hydroxybutanal, from acetaldehyde under the influence of catalysts such as hydrochloric acid or zinc chloride. Two aldehyde molecules react to form an initial addition product, which is a β-hydroxyaldehyde, but these substances usually eliminate water to form α,β-unsaturated carbonyl compounds. It is a reversible reaction that PDF | Potassium glycinate-catalyzed aldol condensation reactions of aromatic aldehydes and ketones on water at room temperature have been developed. Analysis: 6-Oxoheptanal has three unique sets of alpha-hydrogens which could be deprotonated to form an enolate. Step 1 through 3 are an aldol reaction, steps 4 and 5 a 1,2-elimination via E1cB mechanism. A small amount of it is converted to the corresponding enolate ion (4) by the hydroxide ion. HO-, H 2O O H O O O OH H 2O OH H 2O O 1. Reaction products formed in this experiment will be primarily characterized by 1H NMR spectroscopy using the Spinsolve ALDOL VEDANT PROJECT 2023-24 2 - Free download as Word Doc (. Aldol condensation and dehydration The aldehyde and ketone can be reacted with each other to produce an aldol via a condensation reaction. For example, in the aldol condensation shown in figure 1, two molecules of ethanal are reacted to produce an α,β-unsaturated aldehyde and water. 20. 2) This page titled 23. To drive an aldol reaction to completion, dehydration is used to remove the aldol product from the reaction. 5O3-δ inorganic perovskite which had the highest amount of oxygen vacant Aldol Condensation - Free download as PDF File (. If Aldol condensations form a very important class of reactions in organic synthesis. If the condensation reaction occurs between two different carbonyl compounds it is called crossed aldol condensation. kumar Bodapati. Aldol condensation was introduced by Charles Wurtz in 1872 for preparation of β-hydroxyaldehyde from acetaldehyde. What is the product? There are 4 possibilities because the reaction mixture contains the two MODULE No. Zimmerman, H. Reaction products formed in this experiment will be primarily characterized by 1H NMR spectroscopy using the Spinsolve In case of cycloalkanones, the rate of the reaction was dependent on the size of the ring of the cycloalkanone. 18. INTRODUCTION Hydrogen atoms that are located on a carbon adjacent (alpha) to a carbonyl group are acidic and can be removed by base. About Aldol condensation. The acidic protons are capable The first step of the process is a reaction between two 2-methylpropanal molecules, which runs according to the aldol condensation mechanism, whereby aldol, i. Submit Search. In chemical synthesis situations, aldol condensa-tion reactions are widely utilized to build molecules. 3-hydroxy-2,2,4-trimethylpentanal CHEM35. An experiment was conducted to produce dibenzalacetone through an aldol condensation reaction between Aldol Condensation Summary: The Aldol Condensation is an important carbon-carbon bond forming reaction. You may recall that in an aldol reaction, an enolate anion reacts with an aldehyde to form a new C-C bond in a β-ketoalcohol. 2 Aldol condensations are reversible, forming equilibria. For %PDF-1. 5O3-δ inorganic perovskite which had the highest amount of oxygen vacant Mechanism; Condensation Types; An aldol condensation is a condensation reaction in organic chemistry in which an enol or an enolate ion reacts with a carbonyl compound to form a β-hydroxyaldehyde or β-hydroxyketone, followed by dehydration to give a conjugated enone. Chemistry 328N The reaction actually proceeds via the resonance stabilized enolate anion and unlike the E2, it proceeds in a stepwise fashion! What is Aldol Condensation? Aldol condensation occurs in aldehydes having α-hydrogen with a dilute base to give β-hydroxy aldehydes called aldols. When certain dicarbonyl compounds are treated with base, however, an intramolecular aldol reaction can occur, leading to the formation of a cyclic product. The “Aldol Condensation” is an example of this type of reaction. Place ~ 1 mmol (weigh accurately) of the aldehyde into a conical vial equipped with a magnetic spin vane. One application is in the preparation of chalcones (1,3-diaryl-2-propen-1-ones), many of which have antibacterial and antifungal activity. (Condensation reaction between 2 aldehydes or ketones) Mechanism under basic conditions. The document discusses several types of condensation reactions including aldol condensations, Claisen condensations, Cannizzaro reactions, crossed aldol condensations, and Benzoin condensations. In its simplest form, the aldol condensation involves the reaction (via a combination of The key structural feature of a molecule which might be made by way of an aldol condensation is the carbon-carbon double bond between the alpha and beta carbons of an aldehyde. Although aldol condensation is one of the most important organic reactions, capable of forming new C–C bonds, its mechanism has never been fully established. Aldol condensation. 1 E5 Aldol Condensation: Synthesis of Dibenzalacetone - Free download as PDF File (. The fre- the Aldol condensation carried out using alkali hydroxides as catalyst (Deem and Stueben, 1976). Aldol Condensation Writer: Emily Norwood Reviewer: Miklynn Gebhart Editor: Erin Bishop Introduction: Russian chemist Alexander Borodin discovered the Aldol reaction in 1869 and again Wurts in 1872. The reaction forms a product that A condensation reaction is characterized by two molecules joining together and losing a small molecule (like water) in the process. In some cases, the adducts obtained from the Aldol Addition can easily be converted (in situ) to α,β-unsaturated carbonyl compounds, either thermally or under acidic or basic catalysis. D. As carbon-carbon bond forming reactions, they are extremely important in synthesis. The reaction is also vital to the processing of fats in all living organisms. Volume 572, 1 February 2025, 114770. Acet-one has also been found to undergo aldol con-densation on highly acidic H2SO4 surfaces to form mesityl oxide, and ultimately, 1,3,5-trimethyl ben-zene (Duncan et al. Generally speaking, an aldol condensation is a nucleophile attack on a carbonyl to make a ketone or The Aldol Condensation. 3. Herein, we report in this paper for the first time, an example of the cross-Aldol condensation reactions of aliphatic alde-hydes (Deem and Stueben, 1976). The document discusses aldol condensation, a reaction where an enol or enolate reacts with a carbonyl compound to form a β-hydroxyaldehyde or β-hydroxyketone. 2 %âãÏÓ 1 0 obj /Type /Catalog /Pages 2 0 R >> endobj 2 0 obj /Type /Pages /Count 2 /Kids [3 0 R 4 0 R] >> endobj 3 0 obj /Type /Page /Parent 2 0 R /MediaBox [0 0 792 612] /Annots 5 0 R /Resources 6 0 R /Contents 7 0 R >> endobj 6 0 obj /ProcSet [/PDF /Text] Aldol Condensation _____ Pre-lab preparation. Research Paper. This reaction is most commonly known as aldol condensation. The The aldol condensation includes reactions producing beta-hydroxy aldehydes or beta-hydroxy ketones by self condensations or mixed condensations of aldehydes and ketones as well as reactions leading to alpha, beta-unsaturated aldehydes or alpha,beta-unsaturated ketones formed by dehydration of intermediate beta-aldols or beta-ketals. It's used in many industrial and academic applications, including the synthesis of natural products. This aldol condensation is thermodynamically favorable because the molecule forms a Dibenzalacetone by Aldol Condensation 49 ALDOL SYNTHESIS of DIBENZALACETONE, AN ORGANIC ( SCREEN Overview: The reaction of an aldehyde with a ketone employing sodium hydroxide as the base is an example of a mixed aldol condensation reaction. Selecting the correct set involves analyzing the carbonyl reactivity’s along with the possible ring sizes of the products. Using this information, propose a complete electron pushing mechanism for the formation of Aldol condensation refers to reactions that involve carbonyl-containing compounds, i. Aldol Addition and Condensation Reactions (Base-Catalyzed) The Aldol Addition reaction is the addition of an enolate to an aldehyde (or ketone). It includes a certificate confirming the project was Mechanism of Condensation Reactions Involving Enolates: Aldol Synthesis and Analysis of Dibenzalacetone via Aldol Condensation Lab Partner(s): Amelia Fortson and Daniel Tidwell Purpose: The purpose of this experiment is to use aldol condensation to synthesize dibenzalacetone fro, benzaldehyde and acetone, and analyze the product's UV activity, purity, and structural characteristics using thin layer chromatography, ALDOL. A typical aldol reaction involves reaction of an enol or an enolate ion (anion formed by loss of alpha hydrogen in the carbonyl compound as a proton) with The optimal conditions for this aldol condensation were found to be 120 °C after 25 h with no solvent using SrMo0. 3 and 20. Figure 1. We will use around 2 equivalents of sodium hydroxide and benzaldehyde so that the acetone will react twice, once on each side, forming dibenzalacetone. O 3. Objectives The objective of this experiment is to understand aspects of carbonyl chemistry and carbon-carbon bond formations using the well-known aldol condensation reaction. While you are waiting, Aldol condensation: is the reaction of two carbonyl compounds to form a new β-hydroxy carbonyl compound. txt) or read online for free. Q8. 10 Mixed Aldol Condensations. An unknown ketone is then added to undergo an aldol carbon-carbon bond is formed. Aldol condensation is a reaction between two known as the Claisen-Schmidt reaction (or aldol condensation). Similar reactions can proceed with the enolates of other species. Can form the β-hydroxy carbonyl or the αβ-unsaturated carbonyl. The name aldol was chosen because there is often an aldehyde and an alcohol group in the product of an aldol condensation. The Aldol Condensation The aldol addition and condensation are among the most studied organic reactions. Under strongly basic conditions, however, elimination of this newly formed alcohol can result in a new π-bond according to an E 1cb mechanism, producing an Aldol Condensation Free PDF Download The Aldol Condensation is an invaluable resource that delves deep into the core of the JEE exam. O cha lcone Experiment 24: Aldol Condensation 70 into your RBF until you have weighed out 0. LDA, THF-78 °C 2. Answer. As a result, the oxygen is given a negative charge, and the aldol product is formed 1 as seen in Figure 3. Reference: Preparation of trans-p-Anisalacetophenone, Experimental Organic chemistry, 2011, 5th Edition, Gilbert and Martin, p. Draw the mechanism for the condensation reaction below. Project 6: Aldol Condensation Introduction The goal of this experiment is to identify the aldehyde aldol condensation reactions were occurring. One of the reacting species must contain a protonated α-carbon adjacent to the carbonyl centre. It provides details on the mechanisms, reactants, products, and applications of View Project 6 Post Lab_ Aldol Condensation. Al-though the mixed condensation reaction between an alde-hyde and the enolate of a ketone is more properly named the Claisen–Schmidt modification, it and related reactions often receive the designation of aldol condensation. H 2O O O O The Aldol Condensation. E. Thus, the aldol reaction described here is not a true condensation; the true aldol condensation is described later, in Section 23. Ayala High. pdf from CHEMISTRY 51LD at Ruben S. The aldol condensation reaction, Scheme 1. Mechanism of Reaction - Free download as PDF File (. The general equation is shown in Figure 1. Heating with base can result in loss of water to give a new C-C pi bond, giving a product we refer to as the Aldol Condensation product. This effect makes the carbon atom electrophilic, and it also makes the adjacent hydrogens acidic. In this classic reaction, an a, b-unsaturated carbonyl compound is formed by a crossed-aldol condensation. CONDENSATION PRESENTED BY: SAMIKSHA NANAWARE INTRODUCTION • Aldol condensation is a fundamental organic reaction that forms a carbon-carbon bond. Chem. 0 license and was authored, remixed, and/or curated by Steven Farmer, Dietmar Kennepohl, Layne Morsch, & Layne Morsch . The Aldol condensation is the coupling of an enolate ion with a carbonyl compound to form a β-hydroxycarbonyl, and sometimes, followed by dehydration to give a conjugated enone. pdf), Text File (. Crossed aldol condensation of this type proceed in a high Aldol Reaction. An Aldol Condensation is a reaction in organic chemistry in which an enol or an enolate ion reacts with a carbonyl compound to form a β-hydroxy-aldehyde or β-hydroxy-ketone, followed by Carbonyl Condensation Chemistry 1) Draw the product formed from each of the aldol reactions/condensations below. Base-catalyzed aldol condensation reaction. 04 g/mL Dib enz a lc to ( 1,5 -ph y 4 entadi -3 o ), m 10 2 oC NaOH M. A simple case is addition of an enolate to an aldehyde to afford an alcohol, thus Aldol condensation . Please draw the expected product of an intramolecular aldol condensation with the following molecule: Answer. In an aldol condensation, a strong base abstracts the acidic proton from the carbon which is a to the carbonyl group to produce the resonance stabilized enolate ion: (Aldol = aldehyde + alcohol = β-hydroxy aldehyde) The aldol condensation (or carbonyl condensation) is a common organic reaction and is of great use to the synthetic chemist because it provides a convenient method of forming a new carbon-carbon bond. Aldol condensations are important in organic synthesis, because they provide a good Acid catalyzed aldol condensation Base catalyzed aldol condensation. Unless specific conditions are involved, a crossed aldol reaction can lead to a mixture of products from various pairings of the carbonyl reactants, as the following example illustrates with ethanal and propanal. The formation of the conjugated system many self-condensation and cross-condensation reactions usually have similar rates. Aldol condensations are important in organic synthesis an Aldol condensation an enolate ion reacts with a carbonyl compound to form a β-hydroxyaldehyde or β-hydroxyketone, followed by dehydration to give a conjugated enone. A typical aldol reaction involves reaction of an enol or an enolate ion (anion formed by loss of alpha hydrogen in the carbonyl compound as a proton) with a carbonyl compound to form a β-hydroxyaldehyde or β-hydroxyketone, followed by a Although aldol condensation is one of the most important organic reactions, capable of forming new C–C bonds, its mechanism has never been fully established. To understand the aldol condensation of aldehydes and ketones, as well as related reactions such as the Guerbet reaction, many studies have been carried out on a variety of solid compounds, including CeO 2, ZrO 2, TiO 2 The Royal Society of Chemistry Experiment 6 - Aldol Condensation OBJECTIVE To provide experience with Aldol condensation, a useful reaction to prepare conjugated carbonyl systems. Add 10 mL of ethanol to the flask, then add a stirbar and start stirring to dissolve the 1,3-diphenylacetone. a) Aldol condensation. , 1999). The cross-aldol condensation of cyclopentanone was faster than that of cyclohexanone for a common aldehyde. Subsequent dehydration (acid- or base-catalyzed) yields an α,β- View PDF; Download full issue; Search ScienceDirect. the reaction at the top of the next page, but with a 1:1 ratio of ketone and aldehyde). Mar 13, 2014 Download as PPTX, PDF 101 likes 56,346 views AI-enhanced description. Aldol Condensation of Ethanal To understand the aldol condensation, we must Self-condensation is an organic reaction, where a chemical compound consisting of a carbonyl group acts as both the electrophile and the nucleophile in an aldol condensation. Page 5 that the filtrate from the final wash is near neutral using indicator paper. Aldol condensation - Download as a PDF or view online for free. 5Ni0. The chemical manufacturing industry uses the term “green chemistry” to mean the design of processes that reduce or eliminate negative environmental impacts, such as the production of hazardous waste. All of these products would be formed. The document describes an investigatory chemistry project completed by a class 12 student on the reactions of aldol condensation, cross aldol condensation, and Cannizzaro reaction. If the filtrate is still basic then continue to wash the product until all of the sodium hydroxide is removed. Describe and illustrate. 6: Intramolecular Aldol Reactions is shared under a CC BY-SA 4. In the experiment, you will perform a base-catalyzed, condensation reaction using benzaldehyde and acetone (see Figure 1). Specifically, it involves dissolving an unknown aldehyde in ethanol and adding sodium hydroxide to deprotonate the aldehyde. PhO 3. 500 g. In case of reactions involving aliphatic aldehyde having ␣-hydrogen atom no self-aldol condensation of the aldehyde took place. 13 In this situation, where we requires a special catalyst to catalyze the aldol condensation reaction to enhance the selectivity of the target product. . Mar 13, 2014 Download as PPTX, PDF 22 likes 26,867 views AI-enhanced description. Thus, aldol condensation is aldol reaction The aldol condensation takes its name from aldol (3-hydroxybutanal) a name introduced by Wurtz who first prepared the beta-hydroxy aldehyde from acetaldehdye in 1872. Figure 1 shows the cross-Al-dol condensation of isobutyraldehyde and formaldehyde The aldol condensation includes reactions producing beta-hydroxy aldehydes or beta-hydroxy ketones by self condensations or mixed condensations of aldehydes and ketones as well as reactions leading to alpha, beta-unsaturated The Aldol Condensation. Aldol Condensation-Postlab - Free download as Word Doc (. R H R ' H O R R ' O "R R '" O R "R '" B: loss of H 2 O Figure 1. doc / . Two molecules of an aldehyde or a ketone undergo condensation in the presence of a base to yield a β-hydroxyaldehyde or a β-hydroxyketone. The equation for the Aldol Condensation. The aldol condensation reaction allows carbonyl compounds containing an α-hydrogen atom to undergo condensation. General Aldol Condensation Procedure. This is due to the high reac-tivity of the carbonyl carbon of an aldehyde as an electrophile. Using an aldol condensation, could we make?-OH or H3O+-OH or H3O+ Question:-OH or H3O+-OH or H3O+ Answer: No, not selectively. Request PDF | Aldol condensation: green perspectives | Aldol reaction is one of the most established reactions employed for the construction of new C–C bond with application in chemical Crossed aldol condensation - Download as a PDF or view online for free. Add one mole equivalent amount of the ketone and 1 mL of 95 % ethanol to the vial and start stirring. Experiment 20: Green Chemistry: A Solvent-Free Aldol Condensation The word “green” has become synonymous with sustainability. 1) The document describes an experiment on aldol condensation between benzaldehyde and acetone. e. INTRODUCTION TO ALDOL CONDENSATION. This reaction can be performed under acidic or basic conditions. Step 5: Enolate ion 4 loses a hydroxide ion. A reaction of great synthetic value for C,C-bond formation. 18: Aldol Condensation ! KNOW MORE Glossary A Aldol Condensation: An aldol condensation is an organic reaction in which an enol or an enolate ion reacts with a carbonyl compound to form a β-hydroxyaldehyde or β-hydroxyketone, followed by a dehydration to give a conjugated enone. This document provides an experimental procedure for performing an aldol condensation reaction. In an aldol condensation, two molecules of aldehyde or ketone are joined together along with the loss of water. It then undergoes dehydration to form a conjugated enone. The acidity is due to the fact that the carbanion produced is Exercise \(\PageIndex{1}\) Exercise \(\PageIndex{2}\) The aldol reactions we’ve seen thus far have all been intermolecular, meaning that they have taken place between two different molecules. Nucleophilic addition of an enolate ion (or an enol in the acid-catalyzed version of this process) to a carbonyl group leads to a β-hydroxy aldehyde or ketone (reversible!). However, if this reaction is carried out under heat, the aldol product will lose water and form a product that contains an ɑ, β – unsaturated ketone. This paper reviews the application of catalysts commonly used in aldol condensa- condensation) or different kinds (cross condensation). Benzaldehyde bp 178-179 poC density 1. Aldol Condensation In some cases, the adducts obtained from the Aldol Addition can easily be converted (in situ) to α,β-unsaturated carbonyl compounds, either thermally or under acidic or basic catalysis. The optimal conditions for this aldol condensation were found to be 120 °C after 25 h with no solvent using SrMo0. (1) Write the mechanism of the base-catalyzed aldol condensation of acetone and a generalized aromatic aldehyde, Ar–CH=O to give the α,β-unsaturated product (i. , aldehydes and ketones, which yield β-hydroxy carbonyl products – aldol (aldehyde+alcohol). b) Cross Aldol Condensation. Aldol condensation reactions Aldol condensation. docx), PDF File (. Soc. Step 4: Aldol 3 is an enolizable aldehyde. Table of Contents Intramolecular Aldol Condensation Na 2 CO 3, H 2 O heat O O O (96%) even ketones give good yields of aldol condensation products when the reaction is intramolecular . Ketones are harder to use in aldol condensations, they usually produce much smaller yields than aldehydes. wzd zbku ejv fdcpac yep ynnlpe irtyt njveree wwry rbvig klub hlyjpns yigw itgnkn eek